TDP-43 self-assembles into oligomers that are able to recruit Aβ to form oligomers of its own, claims a paper in the September 12 Nature Communications. Using a new TDP-43 oligomer antibody, the ...
In most people with ALS, and many with FTD, cytoplasmic aggregates of TDP-43 plague degenerating neurons. What causes an RNA-binding protein that spends most of its time in the nucleus to pile up in ...
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