In pursuit of making molecules, chemists have sought ways to build bonds between unactivated sp 3-hybridized carbons. Although there are chemical catalysts that can accomplish this feat, this kind of ...

Small molecules given lipid ‘tails’ that are not too long or too short can slip through cell membranes and enter living cells 1. Cells are enclosed by a membrane that protects them from intruders, ...

A research team in Japan reports that it has developed a novel branched ionizable lipid which, when included in lipid nanoparticles (LNPs), greatly increases the efficiency of mRNA delivery. The study ...

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station. Thanks to international ...

Messenger RNA (mRNA) therapeutics have moved from a promising idea to clinical reality, accelerating vaccine development and ...

Glycosylphosphatidylinositol (GPI) anchoring is an important post-translational modification, which tethers non-transmembrane proteins to the outer leaflet of the plasma membrane (PM). It participates ...

Researchers have uncovered that phospholipids with two polyunsaturated fatty acyl tails play a crucial role in driving ferroptosis. Ferroptosis is a form of cell death that is dependent on iron.

Scientists at Columbia University report that they have found that a rare type of lipid is a key driver of ferroptosis, a form of cell death. The findings provide new details on how cells die during ...