If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team from IOCB Prague has now described in detail how cells repair this damaged ...

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Throughout the course of our lives, DNA can break in response to natural and environmental factors. However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...

Researchers have uncovered how a key DNA repair enzyme is recruited and activated inside cells, answering long-standing questions about how cells protect and repair their DNA and providing the ...

A bottleneck in ensuring access to widespread molecular diagnostics, especially in low- and middle-income countries, has been the high cost and logistical complexities associated with rapid, ...