For years, a protein inside our cells has quietly powered billions of dollars' worth of cancer drugs. Now a team of ...

A new technique developed by scientists in Spain enables the systematic search for elusive allosteric binding sites on proteins. Applying the method to map allosteric sites of two pharmacologically ...

The GPCRact AI model goes beyond AlphaFold3 by predicting whether drugs functionally activate G-protein-coupled receptors through allosteric signaling.

One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein’s activity can be modulated by binding an ...

Researchers at the Centre for Genomic Regulation have developed a new technique for identifying allosteric sites in proteins (Nature 2022, DOI: 10.1038/s41586-022-04586-4). While many drugs target the ...

Allostery refers to the binding of a metabolite at a site other than the chemically active site of a protein. The existence of allosteric sites on receptor molecules has expanded potential drug ...

Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein’s active site, the spot where its natural substrate clicks in to turn it on or off. Walk into ...

Over the years, a number of methods have been developed to study allostery and its application in different scientific fields such as conformational mechanisms, drug discovery, and various diseases.